Nucleofill Eyes (1x2ml) – Polynucleotide Gel

Description

Nucleofill Eyes (also known as Nucleofill Soft Plus) is a highly specialized, ultra-pure biorestructuring gel developed by Promoitalia (Italy) specifically for the delicate periorbital eye area. Formulated with a lower viscosity molecular weight perfectly calibrated for thin skin regions, it contains highly purified long-chain Polynucleotides (PDRN) at a focused concentration of 7.5 mg/mL (0.75%). Nucleofill Eyes works on a cellular level to reverse periocular aging, hollow under-eyes, and vascular dark circles without the risk of swelling or fluid retention. By stimulating fibroblast activity, scavenging localized free radicals, and optimizing microcirculation, this premium treatment thickens the thin dermal layer around the eyes, smoothing crow’s feet and restoring a refreshed, luminous look.

Main Benefits of Nucleofill Eyes

• Edema-Free Periorbital Rejuvenation: Thickens and firms fragile eye contours without using cross-linked hyaluronic acid, eliminating the risk of water logging, bags, or morning puffiness (Tindall/Tyndall effect).

• Vascular Dark Circle Reduction: Activates local microcirculation and decreases melanin deposition to visibly brighten dark circles and reduce vascular discoloration.

• Deep Dermal Thickenining: Rebuilds the thinning dermal grid around the eyes, creating a denser tissue layer that masks underlying superficial blood vessels.

• Targeted Antioxidant Shielding: Traps free radicals generated by blue light exposure, environmental stressors, and sleep deprivation, arresting premature cellular breakdown.

• Superficial Fine Line Smoothing: Drastically softens the appearance of dynamic crow’s feet, under-eye crinkling, and fine dehydration lines.

Indications

Nucleofill Eyes is precisely indicated for intradermal biorejuvenation and tissue re-densification in the periorbital area across all skin types:

• Dark Circles & Under-Eye Shadows: Brightening tired eyes affected by structural hollowing or dark vascular rings.

• Periorbital Wrinkles & Crow’s Feet: Smoothing out fine lines, superficial expression creases, and crepey texture on the lower and upper eyelids.

• Periocular Skin Laxity: Tightening loose, droopy, or thin skin matrices around the orbital rim.

• Pre- and Post-Surgical Healing: Preparing delicate tissues for blepharoplasty, or speeding up cellular recovery following periocular plasma or fractional laser resurfacing.

Technical Specifications

Feature	Specification
Product Name	Nucleofill Eyes (Nucleofill Soft Plus)
Manufacturer	Promoitalia Group (Italy)
Primary Active Substance	Polydeoxyribonucleotide (PDRN) / Polynucleotide Gel
PDRN Concentration	7.5 mg/mL (0.75%)
Viscosity Index	Medium-low viscoelasticity (Calibrated for periocular safety)
Packaging Layout	1 x 2ml Pre-filled sterile glass syringe per box
Needles Accompanied	2 x 30G 13mm sterile needles
Injection Layer	Intradermal or deep dermal matrix around the orbit
Standard Protocol	2 to 3 initial sessions spaced 2 to 3 weeks apart
Storage Parameters	Store between 2°C to 25°C; protect from heat, freezing, and direct light

Mechanism of Action

Nucleofill Eyes restores the fragile eye contour area through a Cell-Specific Matrix Modification pathway:

1. Fibroblast Receptor Engagement: The 0.75% polynucleotide chains bind to adenosine $A_{2A}$ receptors on local fibroblasts. This triggers the production of Type I collagen and fresh extracellular components, thickening the delicate tissue map.

2. Angiogenesis & Microvascular Boosting: It promotes local capillary microcirculation, enhancing oxygen delivery to the tissues while resolving the blood stagnation responsible for dark under-eye shadows.

3. Iso-Osmotic Water Balance: Unlike standard high-density dermal gels, Nucleofill Eyes releases water molecules slowly as it biodegrades. This guarantees optimal tissue moisture levels without creating localized swelling or lymphatic blockage.

Administration Protocol

• Delivery Techniques: Administered by certified professionals using manual micro-papule injections, nappage sweeps, or linear retrograde threading using small needles or soft, blunt clinical cannulas to minimize bruising risks.

• Injection Depth: Placed cleanly within the intradermal or deep dermal plane of the orbital area. Avoid injecting too deep into the orbital fat pads or too superficial in a high-volume bead, as smooth, widespread delivery is optimal.

• The Recommended Session Cycle:

  • Loading Phase: 2 to 3 treatments spaced 14 to 21 days apart to fully restore cellular structures.

  • Maintenance Phase: 1 single maintenance treatment every 4 to 6 months to sustain the brightened, firm skin matrix.

• Post-Treatment Rules: Minor local papules, slight redness, or small pinpoint bruises may occur around the eye area and resolve naturally within 24 to 48 hours. Patients must avoid rubbing the eye zone for 12 hours, skip eye makeup for 24 hours, and avoid heavy workouts, hot saunas, and intense sun exposure for 3 days.

FAQ

Q: How does Nucleofill Eyes differ from Nucleofill Medium or Strong?

A: The main differences lie in concentration and viscosity. Nucleofill Medium (2%) and Strong (2.5%) feature high concentrations designed to treat thicker facial zones and deep creases. Nucleofill Eyes features a calibrated 0.75% concentration and a fluid consistency, making it completely safe for the ultra-thin skin around the eyes without causing lumps or water retention bags.

Q: Will Nucleofill Eyes help with under-eye tear trough hollowing?

A: It helps by thickening the skin and naturally tightening the area, which softens the transition over the tear trough. However, because it is a biorestructor and not a volumetric dermal filler, it will not physically fill deep structural hollows. For severe tear trough hollows, it is often paired with standard cross-linked fillers or fat grafting.

Q: When will the patient notice the brightened effect under the eyes?

A: Improved skin hydration and subtle softening of fine dry lines are visible within the first week. The definitive skin thickening, reduced dark circles, and reduction in crow’s feet depth develop progressively and peak roughly 3 weeks after the second session.

IMPORTANT NOTICE ON INTELLECTUAL PROPERTY

This digital storefront operates as an independent, autonomous merchant of authentic medical aesthetic products. We hold no formal commercial relationship, corporate partnership, or authorized distribution agreements with Promoitalia Group, its international branches, or the Nucleofill product brand. All brand names, logos, technical titles, and registered trademarks listed here are the property of their respective owners. Their use on this site is solely for identifying and describing the authentic products we independently distribute.