ELLANSÉ M (2x1ml) – Polycaprolactone (PCL)

Description

ELLANSÉ M is a groundbreaking, dual-action injectable dermal filler and biostimulator developed by Sinclair (UK). It represents an innovative shift away from traditional hyaluronic acid gels by offering Tunable Longevity Performance via STAT Technology™. This advanced formulation consists of synthetic Polycaprolactone (PCL) microspheres (30%) completely suspended within a smooth, biocompatible Carboxymethylcellulose (CMC) gel carrier (70%). Upon injection, ELLANSÉ M provides immediate mechanical lifting and wrinkle correction. As the CMC carrier gel gradually resorbs over the following months, the perfectly smooth PCL microspheres remain behind, acting as a powerful scaffolding network that commands the body to synthesize fresh Type I collagen. The “M” variant is precisely engineered to maintain its structural volume and aesthetic results for up to 24 months, making it a premier choice for long-lasting facial contouring and structural correction.

Main Benefits of ELLANSÉ M

• Immediate Volume & Progressive Rejuvenation: The CMC gel matrix delivers instant projection and fold-filling, while the embedded PCL micro-scaffolds trigger long-term structural neocollagenesis.

• Predictable 2-Year Longevity: Engineered with optimal polymer chain lengths to ensure that structural corrections, contour definitions, and volume remain stable for a full 24 months.

• Pure Type I Collagen Stimulation: Triggers the generation of soft, natural Type I collagen—the same collagen abundant in youthful skin—avoiding stiff or unnatural tissue textures.

• Total Bioresorbability: Both the CMC gel and PCL microspheres are slowly broken down by natural metabolic pathways into water and carbon dioxide, leaving behind no permanent foreign residues.

• Cost-Effective High Projection: Features an exceptional G-Prime (elastic modulus) that provides superior lifting capability per milliliter compared to standard hyaluronic acid fillers.

Indications

ELLANSÉ M is indicated for deep dermal or subcutaneous placement to restore facial fat volume, redefine bone architecture, and correct deep facial folds:

• Mid-Face & Cheek Volumization: Restoring lost volume to flat or hollow malar and submalar areas.

• Nasolabial Folds & Marionette Lines: Smoothing out deep facial expression folds that form around the nose and mouth.

• Temporal Hollowing: Filling sunken temples to restore a smooth, continuous upper-facial perimeter.

• Jawline Definiton & Chin Augmentation: Creating sharp structural jaw contours and correcting weak, recessed chin profiles.

• Nose Reshaping (Non-Surgical Rhinoplasty): Reshaping minor nasal dorsal humps or lifting the nasal tip without surgery.

Technical Specifications

Feature	Specification
Product Name	ELLANSÉ M
Manufacturer	Sinclair / AQTIS Medical (Netherlands/UK)
Active Microspheres	30% Polycaprolactone (PCL) smooth spherical microparticles (25-50 microns)
Carrier Component	70% Carboxymethylcellulose (CMC) cohesive gel matrix
Packaging Layout	2 x 1ml Pre-filled sterile single-use syringes per box
Total Gel Volume	2ml total structural yield per retail box
Included Needles	4 x 27G ¾” sterile single-use needles
Injection Layer	Subcutaneous layer, deep dermis, or supra-periosteal (on bone)
Duration of Results	Up to 24 months (Stable volume throughout the entire period)
Storage Parameters	Store between 15°C to 25°C in a dry environment; protect from direct heat and freezing

Mechanism of Action

ELLANSÉ M works through an advanced Dual-Phase Controlled Bioresorption pathway:

1. Immediate Mechanical Projection: The smooth carboxymethylcellulose (CMC) gel carrier instantly fills out sunken dermal planes upon injection, smoothing creases and providing immediate structural support.

2. Stable PCL Scaffolding: Over the first few months, the CMC carrier gel is gently resorbed by the body. The PCL microspheres remain exactly where placed, forming a uniform grid that stimulates a mild, localized cellular response.

3. Active Neo-Collagenesis: Fibroblasts flock to the PCL microspheres, encapsulating each smooth sphere in a thick, fresh matrix of Type I collagen. This process replaces the resorbing CMC gel one-for-one with the patient’s own natural structural tissue.

4. Synchronized Degradation (STAT Technology™): Unlike other fillers that lose volume gradually month-by-month, the PCL microspheres in ELLANSÉ M maintain their physical size for up to 2 years. Once the polymer chains reach their pre-determined degradation point, they are quickly and safely metabolized into water and carbon dioxide.

Administration Protocol

• Delivery Formats: Administered exclusively by trained medical professionals using precise placement strategies. Common approaches include bolus placement directly onto the bone for chin/malar definition, or smooth linear retrograde threading and fanning patterns using a blunt micro-cannula (typically 22G to 25G) for wide areas.

• Optimal Placement Depth: Must be placed cleanly within the deep dermis, the subcutaneous fat plane, or supra-periosteally. Shallow injection into the superficial dermis or epidermis must be strictly avoided to prevent the formation of visible white nodules or surface irregularities.

• Post-Injection Massage: Firm massage must be performed by the injector immediately after delivery to ensure the PCL suspension settles smoothly and evenly within the target tissue.

• Aftercare Instructions: Patients should expect mild swelling, redness, or localized tenderness for 24 to 72 hours. Advise them to avoid heavy exercise, saunas, hot baths, and direct sun exposure for 48 hours post-treatment.

FAQ

Q: What is the primary difference between ELLANSÉ S and ELLANSÉ M?

A: Both products share identical ingredients (30% PCL, 70% CMC gel) and provide an identical immediate lifting effect. The only difference lies in the length of the PCL polymer chains, which dictates how long they last. ELLANSÉ S maintains its structural results for up to 12 months, whereas ELLANSÉ M is engineered to sustain its volume and collagen matrix for up to 24 months.

Q: Can ELLANSÉ M be dissolved with hyaluronidase if needed?

A: No. Hyaluronidase enzymes only break down hyaluronic acid fillers. Because ELLANSÉ M is made of Polycaprolactone (PCL) and CMC gel, it cannot be dissolved. Therefore, accurate deep placement by an experienced injector who understands facial anatomy is essential.

Q: Is ELLANSÉ M suitable for lip augmentation or the under-eye area?

A: No. ELLANSÉ M is strictly contraindicated for injection into the lips (vermilion border/body) and the periorbital zone (tear troughs or eyelids). These thin-skinned, highly mobile muscle areas can cause the PCL microspheres to clump, creating a high risk of visible nodules and lumps.

IMPORTANT NOTICE ON INTELLECTUAL PROPERTY

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