Rejuran Healer – Polynucleotides (PN)

Description

Rejuran Healer is a highly acclaimed, state-of-the-art skin-bioremodeling treatment manufactured by PharmaResearch Products (South Korea). Distinct from conventional hyaluronic acid dermal fillers or superficial mesotherapy boosters, it is formulated with pure, highly biocompatible Polynucleotides (PN) extracted from wild salmon DNA using patented DOT™ Technology (DNA Optimizing Technology). This powerful cellular mediator operates at the molecular level, delivering standardized DNA fragments directly into the dermis to heal damaged, thinning, and aging skin from within. Rejuran Healer works effectively as a biological wound-healing catalyst—it reverses sun damage, suppresses chronic inflammation, accelerates tissue regeneration, and thickens the extracellular matrix. By restoring the optimal physiological environment of the dermis, it improves skin elasticity, smooths fine lines, tightens enlarged pores, and delivers a healthy, radiant bounce back to compromised skin profiles.

Main Benefits of Rejuran Healer

• Advanced Cellular Regeneration: Delivers active PN fragments that directly speed up fibroblast cell multiplication, actively replacing worn-out or damaged skin structures with fresh, healthy tissue.

• Dermal Matrix Thickening: Systematically reverses age-related skin thinning by densifying the extracellular matrix, restoring natural cushion, volume, and protective barrier strength.

• Sebum Regulation & Pore Refining: Balances skin oil production, significantly reducing excessive sebum output and shrinking stretched pore walls for a smoother texture.

• Powerful Anti-Inflammatory Action: Calmly down-regulates pro-inflammatory signals, making it highly effective at clearing redness, repairing acne scarring, and healing skin sensitized by aggressive laser procedures.

• Proven Skin Elasticity Boost: Stimulates a balanced, natural synthesis of both fresh structural collagen and elastin fibers, smoothing out stubborn fine wrinkles and crepe-like skin texture.

Indications

Rejuran Healer is uniquely indicated for full-face or targeted micro-injection protocols to treat structural depletion, barrier damage, and texture irregularities:

• Full-Face Structural Rejuvenation: Reversing generalized skin thinning, sallow dullness, and loss of facial elasticity.

• Periorbital and Perioral Crepiness: Smoothing delicate, paper-thin fine lines surrounding the eyes (crow’s feet) and lips (smoker’s lines).

• Acne Scarring and Textural Indentations: Filling out and softening atrophic acne scars by remodeling underlying fibrotic tissues.

• Post-Procedure Recovery: Accelerating cellular repair and reducing downtime following ablative lasers, chemical peels, or RF microneedling.

• Compromised Skin Barrier Repair: Treating overly sensitive, chronically dry, or inflamed skin conditions caused by environmental stress or product misuse.

Technical Specifications

Feature	Specification
Product Name	Rejuran Healer
Manufacturer	PharmaResearch Products Co., Ltd. (South Korea)
Active Substrate	Polynucleotide (PN) derived from salmon DNA (20 mg/mL)
Concentration Profile	2% Polynucleotide gel network
Crosslinking Type	100% Free of chemical crosslinkers (Non-HA biological gel)
Packaging Layout	2 x 2ml Pre-filled sterile single-use glass syringes per box
Total Fluid Yield	4ml total treatment volume per retail box
Included Needles	2 x 33G 4mm ultra-fine sterile single-use needles
Injection Layer	Superficial to deep dermis (Intradermal papule method)
Standard Session Cycle	3 to 4 loading sessions spaced 3 to 4 weeks apart
Duration of Efficacy	6 to 12 months after completing the full loading cycle
Storage Parameters	Store between 1°C to 30°C; do not freeze; keep away from direct light

Mechanism of Action

Rejuran Healer remodels damaged skin structures through a multi-step Biological Scaffold and Cellular Recovery pathway:

1. Mechanical Matrix Support: Upon micro-injection into the dermal layer, the long-chain polynucleotide polymers immediately create a supportive physical grid. This grid traps moisture and provides instant structural architecture to surrounding cells.

2. Salvage Pathway Activation: The PN microparticles steadily break down into basic purine and pyrimidine bases. These molecules are absorbed by skin cells via the cellular “salvage pathway,” saving cells the metabolic energy of building new DNA from scratch, which greatly accelerates tissue healing.

3. A2A Receptor Signaling: The DNA fragments selectively bind with cell-surface adenosine A2A receptors. This signaling pathway clears away inflammatory cytokines, reduces redness, and instructs local fibroblasts to multiply.

4. Neocollagenesis & Matrix Rebalancing: The newly multiplied fibroblasts synthesize a balanced blend of Type I collagen and elastin fibers. This micro-structural remodeling progressively thickens the dermis, tightens open pores, and restores firm skin tone.

Administration Protocol

• Delivery Formats: Administered by qualified medical professionals using an intradermal micro-papule technique. The injector delivers minute droplets of the product (roughly 0.02ml to 0.05ml per point) spaced 0.5cm to 1cm apart across the target skin zones. Alternatively, it can be smoothly laid down using a mechanical multi-needle meso-injector gun or a specialized 27G/30G blunt cannula.

• Optimal Placement Depth: Must be deposited squarely into the superficial to deep dermis. Shallow, uniform delivery ensures the polynucleotides interact directly with the high density of fibroblasts located in the dermal matrix.

• The Recommended Session Cycle:

  • Phase 1 (Initial Loading): 3 to 4 separate treatment sessions spaced precisely 3 to 4 weeks apart. This builds up the cellular matrix incrementally.

  • Phase 2 (Long-Term Maintenance): 1 single touch-up session every 6 months to preserve cellular energy, matrix density, and skin barrier resilience.

• Post-Treatment Expectations: Regular, visible micro-papules (small raised bumps) will form at every injection site immediately following the session. This is a normal hallmark of the treatment and signifies the product is resting within the dermis. These bumps naturally diffuse and disappear completely within 24 to 72 hours. Advise patients to avoid intense heat, workouts, and makeup application until the micro-punctures close.

FAQ

Q: Is Rejuran Healer a traditional dermal filler?

A: No. Rejuran Healer does not contain crosslinked hyaluronic acid and does not add artificial, mechanical volume to the face like a filler. Instead, it is a cellular repair biostimulator. It infuses salmon-derived polynucleotides into the dermis to heal and regenerate skin tissue from within, which organically improves skin density, elasticity, and health.

Q: Can patients with seafood allergies safely receive Rejuran Healer?

A: Yes, in the vast majority of cases. The polynucleotides in Rejuran are extracted using rigorous, multi-step purification methods (DOT™ Technology) that strip away all salmon proteins and cellular impurities, leaving behind only ultra-pure, biocompatible DNA fragments. However, as a precaution, patients with severe, anaphylactic responses to seafood should undergo a small patch test prior to a full session.

Q: When will my patients notice visible results from the treatment?

A: Skin healing is a gradual, biological process. During the first 1 to 2 weeks, patients typically notice a balancing of skin oils, smoother texture, and improved moisture levels. The true structural changes—such as skin tightening, decreased pore size, softened acne scars, and improved elasticity—develop more prominently around week 4 to 6, following the second loading session.

IMPORTANT NOTICE ON INTELLECTUAL PROPERTY

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